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AKIN Studies
Several large single center studies demonstrated that small changes
in kidney function occur in 18 to 60% of patients and are associated
with increased risk for mortality [1-4]. The Acute Kidney
Injury Network (AKIN) (www.AKINet.org) has proposed a definition
of AKI based on the RIFLE classification [5] (table 1). AKI stages define
the whole spectrum of AKI from moderate to severe deterioration
of kidney function (table 2). Because AKI impacts so enormously
on resources and outcomes it is important to understand the true
magnitude of its epidemiology.
We invite you to participate in one or more of the prospective,
multinational, multicenter studies currently being developed to
measure the incidence, prevalence, risk factors, treatment and outcome
of AKI. Centers anywhere in the world are welcome to participate.
Please click on Join AKIN to submit your
information and you will be added to our investigator registry.
Subsequently you will receive information about available trials
through AKIN.
References
1. Lassnigg A, Schmidlin D, Mouhieddine M, Bachmann LM, Druml W,
Bauer P, Hiesmayr M:
Minimal changes of serum creatinine predict prognosis in patients
after cardiothoracic surgery:
a prospective cohort study. J Am Soc Nephrol 2004, 15:1597-1605.
2. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW:
Acute kidney injury, mortality, length of stay, and costs in hospitalized
patients.
J Am Soc Nephrol 2005, 16:3365-3370.
3. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De
Bacquer D, Kellum JA:
RIFLE criteria for acute kidney injury are associated with hospital
mortality in critically ill patients: a cohort analysis. Crit
Care 2006, 10:R73.
4. Uchino S, Bellomo R, Goldsmith D, Bates S, Ronco C:
An assessment of the RIFLE criteria for acute renal failure in hospitalized
patients. Crit Care Med 2006, 34:1913-1917.
5. Mehta R, Kellum J, Shah S, Molitoris B, Ronco C, Warnock D, Levin A, AKINetwork:
Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury
Critical Care 2007, 11:R31 (doi:10.1186/cc5713) online
at:
http://ccforum.com/content/11/2/R31
or download pdf: AKIN_ICC |
